Horng-Dar（HONDA） WangPersonal data of - Institute of Systems Neuroscience,NTHU

Faculty & Staff

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Name	Horng-Dar（HONDA） Wang
Fax	03-5715934
Personal website	http://hdwlab.weebly.com/

Category	Adjunct
Title	Adjunct Professor
Administrative Affairs	Institute of Biotechnology / Institute of Systems Neuroscience / The Department of Life Sciences / Interdisciplinary Program of Life Science
Discipline	Longevity/ Anti-aging, neurodegeneration, cancer biology.
Research expertise	Longevity/ Anti-aging, neurodegeneration, cancer biology.

Recent Publications
Year	Publication	Author
2018	Yu-Ting Chou, Li-Yang Chen, Shin-Lin Tsai, Hsiao-Chen Tu, Jeng-Wei Lu, Shih-Ci Ciou, Horng-Dar Wang, Chiou-Hwa Yuh. ,2018,Ribose-5-Phosphate Isomerase A Overexpression Promotes Liver Cancer Development in Transgenic Zebrafish via Activation of ERK and β-catenin Pathways. ,Carcinogenesis. ,doi: 10.1093, (SCI)	Horng-Dar（HONDA） Wang
2018	Huang HW, Lin YH, Lin MH, Huang YR, Chou CH, Hong HC, Wang MR, Tseng YT, Liao PC, Chung MC, Ma YJ, Wu SC, Chuang YJ, Wang HD, Wang YM, Huang HD, Lu TT, Liaw WF.,2018,Extension of C. elegans lifespan using the ·NO-delivery dinitrosyl iron complexes.,JBIC Journal of Biological Inorganic Chemistry,23,5,pp775-784 (SCI)	Horng-Dar（HONDA） Wang
2018	Chou YT, Jiang JK, Yang MH, Lu JW, Lin HK, Wang HD, Yuh CH. ,2018,Identification of a noncanonical function for ribose-5-phosphate isomerase A promotes colorectal cancer formation by stabilizing and activating β-catenin via a novel C-terminal domain. ,PLoS Biology. ,16,1,ppe2003714.- (SCI)	Horng-Dar（HONDA） Wang
2017	Lai CJ, Cheng HC, Lin CY, Huang SH, Chen TH, Chung CJ, Chang CH, Wang HD, Chuu CP.,2017,Activation of liver X receptor suppresses angiogenesis via induction of ApoD.,The FASEB Journal.,31,12,pp5568-5576 (SCI)	Horng-Dar（HONDA） Wang
2017	Fan CS, Chen WS, Chen LL, Chen CC, Hsu YT, Chua KV, Wang HD, Huang TS.,2017,Osteopontin-integrin engagement induces HIF-1α-TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer.,Oncotarget.*,9,4,pp4998-5015 (SCI)	Horng-Dar（HONDA） Wang
2017	Ting-Huan Chen, Chen-Yu Chen, Hui-Chin Wen, Chia-Chu Chang, Horng-Dar Wang, Chih-Pin Chuu, Chung-Ho Chang.,2017, YAP Promotes Myogenic Differentiation via the MEK5-ERK5 pathway.,The FASEB Journal.*,31,7,pp2963-2972 (SCI)	Horng-Dar（HONDA） Wang
2017	Hsiao-Chen Tu, Yung-Chun Hsiao, Wan-Yu Yang, Shin-Lin Tsai, Hua-Kuo Lin, Chong-Yi Liao, Jeng-Wei Lu, Yu-Ting Chou, Horng-Dar Wang, and Chiou-Hwa Yuh. ,2017, Upregulation of MAN1A1 and Downregulation of MAN1C1 Activates Unfolded Protein Response During Hepatocarcinogenesis. , Hepatology Communications. ,1,3,pp230-247 (SCI)	Horng-Dar（HONDA） Wang
2017	Chen HD, Kao CY, Liu BY, Huang SW, Kuo CJ, Ruan JW, Lin YH, Huang CR, Chen YH, Wang HD, Aroian RV, Chen CS. ,2017, HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans., Autophagy,13,2,pp371-385 (SCI)	Horng-Dar（HONDA） Wang
2016	Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, ....,Wang HD, etc. ,2016, Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). , Autophagy,12,1,pp1-222 (SCI)	Horng-Dar（HONDA） Wang
2015	Huang CW, Wang HD, Bai H, Wu MS, Yen JH, Fu TF, Tatar M, Wang PY. ,2015,Tequila regulates insulin-like signaling and extends life span in Drosophila melanogaster. , The Journal of Gerontology: Biological Sciences.,70,12,pp1461-1469 (SCI)	Horng-Dar（HONDA） Wang
2015	Hung-Yu Lin, Don-Ching Lee, Horng-Dar Wang, Ya-Hui Chi and Ing-Ming Chiu. ,2015, Activation of FGF1B Promoter and FGF1 Are Involved in Cardiogenesis Through the Signaling of PKC, but Not MAPK. , Stem Cells and Development,24,24,pp2853-2863 (SCI)	Horng-Dar（HONDA） Wang
2015	Wei-Sheng Lin, Cheng-Wen Huang, You-Sheng Song, Jui-Hung Yen, Ping-Chang Kuo, Sheng-Rong Yeh, Hung-Yu Lin, Tsai-Feng Fu, Ming-Shiang Wu, Horng-Dar Wang, Pei-Yu Wang. ,2015, Reduced Gut Acidity Induces an Obese-Like Phenotype in Drosophila melanogaster and in Mice. ,PLoS One ,10,10,ppe0139722- (SCI)	Horng-Dar（HONDA） Wang
2015	Kuo SY, Wu CL, Hsieh MY, Lin CT, Wen RK, Chen LC, Chen YH, Yu YW, Wang HD, Su YJ, Lin CJ, Guan HY, Wang PY, Lan TH, Fu TF. ,2015, PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine. ,Nature Communications ,6,pp7490- (SCI)	Horng-Dar（HONDA） Wang
2015	Shih-Ci Ciou, Yu-Ting Chou, Yu-Ling Liu, Yu-Chin Nieh, Jeng-Wei Lu, Shiu-Feng Huang, Yu-Ting Chou, Li-Hao Cheng, Jeng-Fan Lo, Ming-Jen Chen, Ming-Chi Yang, Chiou-Hwa Yuh, and Horng-Dar Wang. ,2015, Ribose-5-phosphate Isomerase A Regulates Hepatocarcinogenesis via PP2A and ERK Signaling. ,International Journal of Cancer ,137,pp104-115 (SCI)	Horng-Dar（HONDA） Wang
2015	Lin HP, Lin CY, Huo C, Hsiao PH, Su LC, Jiang SS, Chan TM, Chang CH, Chen LT, Kung HJ, Wang HD, Chuu CP. ,2015, Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1. ,Oncotarget ,6,9,pp6684-6707 (SCI)	Horng-Dar（HONDA） Wang
2014	Ming-Lun Kang, Yi-Chun Chen, Shih-Fen Chen, Hsuan-Chao Lin, Yu-Heng Tseng, Horng-Dar Wang. ,2014, The prerequisite of nuclear localization for heat shock protein 27 in modulation of starvation adaptation and longevity in Drosophila. ,Adaptive Medicine ,6,3,pp118-123 (Others)	Horng-Dar（HONDA） Wang
2014	Lai JG, Tsai SM, Tu HC, Chen WC, Kou FJ, Lu JW, Wang HD, Huang CL, Yuh CH.,2014,Zebrafish WNK Lysine Deficient Protein Kinase 1 (wnk1) Affects Angiogenesis Associated with VEGF Signaling.,PLoS One,9,8,ppe106129- (SCI)	Horng-Dar（HONDA） Wang
2014	Yen-Hung Lin, Yi-Chun Chen, Tzu-Yu Kao, Yi-Chun Lin, Tzu-En Hsu, Yi-Chun Wu, William W. Ja, Theodore J. Brummel, Pankaj Kapahi, Chiou-Hwa Yuh, Lin-Kwei Yu, Zhi-Han Lin, Ru-Jing You, Yi-Ting Jhong, and Horng-Dar Wang. ,2014, Diacylglycerol Lipase Regulates Lifespan and Oxidative Stress Response by Inversely Modulating TOR Signaling in Drosophila and C. elegans. ,Aging Cell ,13,4,pp755-764 (SCI)	Horng-Dar（HONDA） Wang
2014	Lu JW, Liao CY, Yang WY, Lin YM, Jin SL, Wang HD, Yuh CH. ,2014, Overexpression of endothelin 1 triggers hepatocarcinogenesis in zebrafish and promotes cell proliferation and migration through the AKT pathway. ,PLoS One ,9,1,ppe85318- (SCI)	Horng-Dar（HONDA） Wang
2013	Lin HP, Lin CY, Hsiao PH, Wang H.-D., Jiang SS, Hsu JM, Jim WT, Chen M, Kung HJ, Chuu CP. ,2013, Difference in Protein Expression Profile and Chemotherapy Drugs Response of Different Progression Stages of LNCaP Sublines and Other Human Prostate Cancer Cells. ,Plos One ,8,12,ppe82625- (SCI)	Horng-Dar（HONDA） Wang
2013	Chen WT, Hung KC, Wen MS, Hsu PY, Chen TH, Wang H.-D., Fang JT, Shie SS, Wang CY. ,2013, Impaired Leukocytes Autophagy in Chronic Kidney Disease Patients. ,CardioRenal Medicine ,3,4,pp254-264	Horng-Dar（HONDA） Wang
2013	Lu JW, Yang WY, Lin YM, Chang PH, Chen JR, Tsai SM, Wang H.-D., Wu JL, Jin SLC, and Yuh CH. ,2013, Liver-specific expressions of HBx and src in the p53 mutant trigger hepatocarcinogenesis in zebrafish. ,Plos One ,8,10,ppe76951- (SCI)	Horng-Dar（HONDA） Wang
2013	Kuo YY, Lin HP, Huo C, Su LC, Yang J, Hsiao PH, Chiang HC, Chung CJ, Wang H.-D., Chang JY, Chen YW, Chuu CP. ,2013, Caffeic acid phenethyl ester suppresses proliferation and survival of TW2.6 human oral cancer cells via inhibition of Akt signaling. ,International Journal of Molecular Sciences ,14,5,pp8801-8817 (SCI)	Horng-Dar（HONDA） Wang
2013	Chou HJ, Lai DM, Huang CW, McLennan IS, Wang, H.-D., Wang PY,2013,BMP4 Is a Peripherally-Derived Factor for Motor Neurons and Attenuates Glutamate-Induced Excitotoxicity In Vitro,Plos One,8,3,ppe58441-	Horng-Dar（HONDA） Wang
2013	Bruce KD, Hoxha S, Carvalho GB, Yamada R, Wang, H.-D., Karayan P, He S, Brummel T, Kapahi P, Ja WW. ,2013, High carbohydrate-low protein consumption maximizes Drosophila lifespan. ,Experimental Gerontology ,10,48,pp1129-1135 (SCI)	Horng-Dar（HONDA） Wang
2012	Kuo SY, Tu CH, Hsu YT, Wang HD, Wen RK, Lin CT, Wu CL, Huang YT, Huang GS, Lan TH, Fu TF. ,2012, A hormone receptor-based transactivator bridges different binary systems to precisely control spatial-temporal gene expression in Drosophila. ,PLoS One ,7,12,ppe50855.- (SCI)	Horng-Dar（HONDA） Wang
2012	Liu H, Wang X, Wang, H.-D., Wu J, Ren J, Meng L, Wu Q, Dong H, Wu J, Kao TY, Ge Q, Wu ZX, Yuh CH, Shan G. ,2012, Escherichia coli noncoding RNAs can affect gene expression and physiology of Caenorhabditis elegans. ,Nature Communications. ,3,pp1073- (SCI)	Horng-Dar（HONDA） Wang
2012	Chen SF, Kang ML, Chen YC, Tang HW, Huang CW, Li WH, Lin CP, Wang CY, Wang PY, Chen GC, Wang, HD. ,2012, Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila. ,Journal of Biomedical Science ,19,pp52- (SCI)	Horng-Dar（HONDA） Wang
2012	Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, …, Wang, H.-D., et al. ,2012, Guidelines for the use and interpretation of assays for monitoring autophagy. ,Autophagy ,8,4,pp445-544 (SCI)	Horng-Dar（HONDA） Wang
2012	Wang CT, Chen YC, Wang YY, Huang MH, Yen TL, Li H, Liang CJ, Sang TK, Ciou SC, Yuh CH, Wang CY, Brummel TJ, Wang, HD. ,2012, Reduced neuronal expression of ribose-5-phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in Drosophila. ,Aging Cell* ,11,1,pp93-103 (SCI)	Horng-Dar（HONDA） Wang
2012	Chao TC, Su WC, Huang JY, Chen YC, Jeng KS, Wang HD, Lai MM. ,2012, PSTPIP2, Proline-Serine-Threonine Phosphatase Interacting Protein 2, a Host Membrane-Deforming Protein, is critical for Membranous Web Formation in Hepatitis C Virus replication. ,Journal of Virology ,86,3,pp1739-1749 (SCI)	Horng-Dar（HONDA） Wang
2012	Lu JW, Hsia Y, Yang WY, Lin YI, Li CC, Tsai TF, Chang KW, Shieh GS, Tsai SF, Wang, HD, Yuh CH. ,2012, Identification of the common regulators for hepatocellular carcinoma induced by hepatitis B virus X antigen in a mouse model. ,Carcinogenesis ,33,1,pp209-219 (SCI)	Horng-Dar（HONDA） Wang
2011	Lu JW, Hsia Y, Tu HC, Hsiao YC, Yang WY, Wang, H.-D., Yuh CH. ,2011, Liver development and cancer formation in zebrafish. ,Birth Defects Res C Embryo Today. ,93,2,pp157-172 (SCI)	Horng-Dar（HONDA） Wang
2011	Chao CH, Tseng WF, Chan TM, Chen HL, Huang CB, Jang TH, Hsu HY, Wang HD, and Yuh, CH. ,2011, Mesendoderm gene regulatory networks in zebrafish. ,Global Journal of Biochemistry ,2,4,pp215-249 (Others)	Horng-Dar（HONDA） Wang
2010	Chao CH, Wang HD, Yuh CH. ,2010, Complexity of Cis-regulatory Organization of Six3a during Forebrain and Eye Development in Zebrafish. , BMC Developmental Biology ,10,pp35- (SCI)	Horng-Dar（HONDA） Wang
2010	Hsin IL, Sheu GT, Chen HH, Chiu LY, Wang HD, Chan HW, Hsu CP, Ko JL. ,2010, N-acetyl Cysteine Mitigates Curcumin-mediated Telomerase Inhibition through Rescuing of Sp1 Reduction in A549 cells. ,Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. ,688,1-2,pp72-77 (SCI)	Horng-Dar（HONDA） Wang
2009	T.-M. Chan, W. Longabaug, H. Bolouri, H.-L. Chen, W.-F. Tseng, C.-H. Chao, T.-H. Jang, Y.-I Lin, S.-C. Hung, H.-D. Wang, and C.-H. Yuh. ,2010,Developmental Gene Regulatory Networks in the Zebrafish Embryo. Biochim. Biophys., Acta-Gene Regul. Mech.,1789,pp279-298 (SCI)	Horng-Dar（HONDA） Wang
2009	Chan TM, Chao CH, Wang HD, Yu YJ, Yuh CH. ,2009, Functional Analysis of the Evolutionarily Conserved Cis-Regulatory Elements on the Sox17 Gene in Zebrafish. ,Developmental Biology ,326,pp456-470 (SCI)	Horng-Dar（HONDA） Wang
2009	Liu YL, Lu WC, Brummel TJ, Yuh CH, Lin PT, Kao TY, Li FY, Liao PC, Benzer S, Wang HD. ,2009, Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. ,Aging Cell* ,8,pp370-379 (SCI)	Horng-Dar（HONDA） Wang
2008	Liao PC, Lin HY, Yuh CH, Yu LK, Wang HD. ,2008, The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration and apoptosis in Drosophila. , Biochemical and Biophysical Research Communications. ,376,pp637-641 (SCI)	Horng-Dar（HONDA） Wang
2004	Horng-Dar Wang, P. Kazemi-Esfarjani, and S. Benzer. ,2004, Multiple-stress analysis for isolation of Drosophila longevity genes. , Proceedings of the National Academy of Science of the United States of America. ,101,pp12610-12615 (SCI)	Horng-Dar（HONDA） Wang
2000	S.S. Johnson, N. Mandavia, H.-D. Wang, and D.L. Johnson,2000,Transcriptional Regulation of the TATA-Binding Protein by Ras Cellular Signaling., Mol. Cell. Biol.,20,pp5000-5009 (SCI)	Horng-Dar（HONDA） Wang
1998	H.-D. Wang, A. Trivedi, and D.L. Johnson. ,1998,Regulation of RNA Polymerase I-Dependent Promoter by the Hepatitis B Virus X Protein via Activated Ras and TATA-binding Protein., Mol. Cell. Biol.,18,pp7086-7094 (SCI)	Horng-Dar（HONDA） Wang
1995	H.-D. Wang, C.-H. Yuh, C.V. Dang, and D.L. Johnson.,1995,The Hepatitis B Virus X Protein Increases the Cellular Level of TATA-binding Protein which Mediates Transactivation of RNA Polymerase III Genes. ,Mol. Cell. Biol.,15,pp6720-6728 (SCI)	Horng-Dar（HONDA） Wang
1994	H.-D. Wang, A. Trivedi, and D.L. Johnson.,1994,Hepatitis B Virus X Protein induces RNA Polymerase III-dependent Gene transcription and Increases Cellular TATA-Binding Protein by Activating the Ras Signaling Pathway., Mol. Cell. Biol. ,17,pp6838-6846 (SCI)	Horng-Dar（HONDA） Wang

Selected book overview
Year	Selected book category	Date of publication	Select book title	Author
2010		2010/09/00	丁信智，朱一民，江樵熹，汪宏達，高茂傑，張雍，陳永昌，曾繁根，焦傳金，黃郁棻，詹明修，劉英麟，蔡瑞瑩，鄭誠功，薛敬和，饒達仁 , Life Sciences and Engineering, 藝軒出版社, Taipei, Taiwan, 978-957-41-7468-3（360）,2010/09	Horng-Dar（HONDA） Wang

Participated event service summary
Category	Event title	Topic	Participant
(研討會)	The 11th Annual Meeting on the Asia Pacific Society for Molecular Immunohistology （APSMI）	None. served as a poster reviewer.	Horng-Dar（HONDA） Wang

Patent overview
Year	Patent category	Patent title	Date (Year/Month)	Patent owner
2013	其他		2013-11-00	Horng-Dar（HONDA） Wang
2013	其他		2013-09-00	Horng-Dar（HONDA） Wang

Honors & Awards (NTHU)
Year of award	Name of award	Awarded by
2018	Outstanding Mentor Award.
2016	Excellent Research Award	National Tsing Hua University
2015	Outstanding Research Award	National Tsing Hua University
2015	Outstanding Teaching Award, College of Life Science, National Tsing Hua University	National Tsing Hua University, College of Life Science
2015	Outstanding Teaching Award	National Tsing Hua University
2014	Outstanding Research Award	National Tsing Hua University
2013	Excellent Publication Award	National Tsing Hua University
2013	Outstanding Research Award	National Tsing Hua University
2011	Outstanding Teaching Award	National Tsing Hua University
2010	Outstanding Thesis Award	College of Life Science, National Tsing Hua University
2010	Outstanding Publication Award	National Tsing Hua University
2009	New Faculty Outstanding Publication Award	College of Life Science, National Tsing Hua University
2008	New Faculty Outstanding Teaching Award	College of Life Science, National Tsing Hua University

Honors & Awards (outside NTHU)
Year of award	Name of award	Awarded by
2016	榮台聯大合作研究優良壁報獎第一名- 核糖5磷酸異構酶於大腸直腸癌之作用機轉研究	榮台聯大
2016	Editorial Board (2016~ present)	International Journal of Neurological Disorders & Interventions
2016	新竹縣政府醫事審議委員會委員(2016~2018)	Hsinchu County
2016	Editorial Board (2016 ~ present)	Journal of Pharmacovigilance and Pharmacotherapeuticsis
2016	Editorial Board (2016-present)	Madridge Journal of Neuroscience
2015	Editorial Board (2015-2018)	Reactive Oxygen Species
2014	Editorial Board	Science Postprint
2014	Editorial Board (2014-2016)	Adaptive Medicine
2014	Editorial Board	Journal of Biotechnology Science Research
2014	Editorial Board (2014-2016)	International Journal of Biological Sciences and Applications
2013	Editorial Board (2013-2015)	American Journal of Life Sciences
2013	中華民國優良廠商協會產學合作指導顧問暨評鑑委員會評鑑委員	中華民國優良廠商協會
2012	Research Award	Liver Disease Prevention and Treatment Research Foundation
2000	Postdoctoral Fellowship	John Douglas French Alzheimer’s Foundation, USA
2000	Postdoctoral Research Fellowship	National Institute of Aging, NIH, USA
1996	Charles & Charlotte Krown Fellowship	School of Pharmacy, USC.
1996	Pharmaceutical Research and Manufactures of America Fellowship	Pharmaceutical Research and Manufactures of America Foundation, USA

Educational background summary
School name	Country	Department	Degree	Starting date
California Institute of Technology	USA	Division of Biology	Post-Doctoral Scholar （with Dr. Seymour Benzer）	1999-01 ~ 2004-06
University of Southern California	USA	Department of Molecular Pharmacology and Toxicology	Post-Doctoral Fellow （with Dr. Deborah L. Johnson）	1998-01 ~ 1998-12
University of Southern California	USA	Department of Molecular Pharmacology and Toxicology	Ph.D. （Mentor: Dr. Deborah L. Johnson）	1992-09 ~ 1997-12

Service organization/unit	Title	Department	Starting date
National Tsing Hua University	Adjnuct Professor	Institute of Systems Neuroscience	2015-08 ~
National Tsing Hua University	Adjunct Associate Professor	Institute of Systems Neuroscience	2012-11 ~ 2015-07
National Tsing Hua University	Associate Professor	Institute of Biotechnology / Department of Life Science	2009-08 ~ 2015-07
National Tsing Hua University	Assistant Professor	Institute of Biotechnology / Department of Life Science	2004-08 ~ 2009-07
Development Center for Biotechnology	Research Assistant	Division of Molecular Biology	1989-06 ~ 1991-06

Institute of Systems Neuroscience,NTHU

Faculty & Staff

標準版RSs 2.x套裝

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