汪宏達的個人資料 - 清華大學生命科學院系統神經科學研究所

本所成員

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姓名	汪宏達
傳真	03-5715934
個人網站	http://hdwlab.weebly.com/
職銜	生物科技研究所所長

類別	合聘教師
職稱	合聘教授
單位別	生物科技研究所 / 系統神經科學研究所 / 生命科學系 / 學士班
授課領域	長壽抗老化、神經退化疾病、癌症生物學
研究專長	長壽抗老化、神經退化疾病、癌症生物學

期刊論文一覽
年度	著作	著作人
2018	Chou YT, Jiang JK, Yang MH, Lu JW, Lin HK, Wang HD, Yuh CH.,2018,Identification of a noncanonical function for ribose-5-phosphate isomerase A promotes colorectal cancer formation by stabilizing and activating β-catenin via a novel C-terminal domain.,PLoS Biology.,16,1,ppe2003714.- (SCI)	汪宏達
2017	Lai CJ, Cheng HC, Lin CY, Huang SH, Chen TH, Chung CJ, Chang CH, Wang HD, Chuu CP.,2017,Activation of liver X receptor suppresses angiogenesis via induction of ApoD.,The FASEB Journal.,31,12,pp5568-5576 (SCI)	汪宏達
2017	Fan CS, Chen WS, Chen LL, Chen CC, Hsu YT, Chua KV, Wang HD, Huang TS.,2017,Osteopontin-integrin engagement induces HIF-1α-TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer.,Oncotarget.*,9,4,pp4998-5015 (SCI)	汪宏達
2017	Ting-Huan Chen, Chen-Yu Chen, Hui-Chin Wen, Chia-Chu Chang, Horng-Dar Wang, Chih-Pin Chuu, Chung-Ho Chang.,2017, YAP Promotes Myogenic Differentiation via the MEK5-ERK5 pathway.,The FASEB Journal.,31,7,pp2963-2972 (SCI)	汪宏達
2017	Hsiao-Chen Tu, Yung-Chun Hsiao, Wan-Yu Yang, Shin-Lin Tsai, Hua-Kuo Lin, Chong-Yi Liao, Jeng-Wei Lu, Yu-Ting Chou, Horng-Dar Wang, and Chiou-Hwa Yuh. ,2017, Upregulation of MAN1A1 and Downregulation of MAN1C1 Activates Unfolded Protein Response During Hepatocarcinogenesis. , Hepatology Communications. ,1,3,pp230-247 (SCI)	汪宏達
2017	Chen HD, Kao CY, Liu BY, Huang SW, Kuo CJ, Ruan JW, Lin YH, Huang CR, Chen YH, Wang HD, Aroian RV, Chen CS. ,2017, HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans., Autophagy,13,2,pp371-385 (SCI)	汪宏達
2016	Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, ....,Wang HD, etc. ,2016, Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). , Autophagy,12,1,pp1-222 (SCI)	汪宏達
2015	Huang CW, Wang HD, Bai H, Wu MS, Yen JH, Fu TF, Tatar M, Wang PY. ,2015,Tequila regulates insulin-like signaling and extends life span in Drosophila melanogaster. , The Journal of Gerontology: Biological Sciences.,70,12,pp1461-1469 (SCI)	汪宏達
2015	Hung-Yu Lin, Don-Ching Lee, Horng-Dar Wang, Ya-Hui Chi and Ing-Ming Chiu. ,2015, Activation of FGF1B Promoter and FGF1 Are Involved in Cardiogenesis Through the Signaling of PKC, but Not MAPK. , Stem Cells and Development,24,24,pp2853-2863 (SCI)	汪宏達
2015	Wei-Sheng Lin, Cheng-Wen Huang, You-Sheng Song, Jui-Hung Yen, Ping-Chang Kuo, Sheng-Rong Yeh, Hung-Yu Lin, Tsai-Feng Fu, Ming-Shiang Wu, Horng-Dar Wang, Pei-Yu Wang. ,2015, Reduced Gut Acidity Induces an Obese-Like Phenotype in Drosophila melanogaster and in Mice. ,PLoS One ,10,10,ppe0139722- (SCI)	汪宏達
2015	Kuo SY, Wu CL, Hsieh MY, Lin CT, Wen RK, Chen LC, Chen YH, Yu YW, Wang HD, Su YJ, Lin CJ, Guan HY, Wang PY, Lan TH, Fu TF. ,2015, PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine. ,Nature Communications ,6,pp7490- (SCI)	汪宏達
2015	Shih-Ci Ciou, Yu-Ting Chou, Yu-Ling Liu, Yu-Chin Nieh, Jeng-Wei Lu, Shiu-Feng Huang, Yu-Ting Chou, Li-Hao Cheng, Jeng-Fan Lo, Ming-Jen Chen, Ming-Chi Yang, Chiou-Hwa Yuh, and Horng-Dar Wang. ,2015, Ribose-5-phosphate Isomerase A Regulates Hepatocarcinogenesis via PP2A and ERK Signaling. ,International Journal of Cancer ,137,pp104-115 (SCI)	汪宏達
2015	Lin HP, Lin CY, Huo C, Hsiao PH, Su LC, Jiang SS, Chan TM, Chang CH, Chen LT, Kung HJ, Wang HD, Chuu CP. ,2015, Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1. ,Oncotarget ,6,9,pp6684-6707 (SCI)	汪宏達
2014	Ming-Lun Kang, Yi-Chun Chen, Shih-Fen Chen, Hsuan-Chao Lin, Yu-Heng Tseng, Horng-Dar Wang. ,2014, The prerequisite of nuclear localization for heat shock protein 27 in modulation of starvation adaptation and longevity in Drosophila. ,Adaptive Medicine ,6,3,pp118-123 (Others)	汪宏達
2014	Lai JG, Tsai SM, Tu HC, Chen WC, Kou FJ, Lu JW, Wang HD, Huang CL, Yuh CH.,2014,Zebrafish WNK Lysine Deficient Protein Kinase 1 (wnk1) Affects Angiogenesis Associated with VEGF Signaling.,PLoS One,9,8,ppe106129- (SCI)	汪宏達
2014	Lin YH, Chen YC, Kao TY, Lin YC, Hsu TE, Wu YC, Ja WW, Brummel TJ, Kapahi P, Yuh CH, Yu LK, Lin ZH, You RJ, Jhong YT, Wang HD. ,2014, Diacylglycerol Lipase Regulates Lifespan and Oxidative Stress Response by Inversely Modulating TOR Signaling in Drosophila and C. elegans. ,Aging Cell ,13,4,pp755-764 (SCI)	汪宏達
2014	Jeng-Wei Lu, Chung-Yi Liao, Wan-Yu Yang, Yueh-Min Lin, Shiow-Lian Catherine Jin, Horng-Dar Wang, and Chiou-Hwa Yuh. ,2014, Overexpression of endothelin 1 triggers hepatocarcinogenesis in zebrafish and promotes cell proliferation and migration through the AKT pathway. ,PLoS One ,9,1,ppe85318- (SCI)	汪宏達
2013	Lin HP, Lin CY, Hsiao PH, Wang H.-D., Jiang SS, Hsu JM, Jim WT, Chen M, Kung HJ, Chuu CP. ,2013, Difference in Protein Expression Profile and Chemotherapy Drugs Response of Different Progression Stages of LNCaP Sublines and Other Human Prostate Cancer Cells. ,Plos One ,8,12,ppe82625- (SCI)	汪宏達
2013	Chen WT, Hung KC, Wen MS, Hsu PY, Chen TH, Wang H.-D., Fang JT, Shie SS, Wang CY. ,2013, Impaired Leukocytes Autophagy in Chronic Kidney Disease Patients. ,CardioRenal Medicine ,3,4,pp254-264	汪宏達
2013	Lu JW, Yang WY, Lin YM, Chang PH, Chen JR, Tsai SM,Wang H.-D., Wu JL, Jin SLC, and Yuh CH. ,2013, Liver-specific expressions of HBx and src in the p53 mutant trigger hepatocarcinogenesis in zebrafish. ,Plos One ,8,10,ppe76951- (SCI)	汪宏達
2013	Kuo YY, Lin HP, Huo C, Su LC, Yang J, Hsiao PH, Chiang HC, Chung CJ, Wang H.-D., Chang JY, Chen YW, Chuu CP. ,2013, Caffeic acid phenethyl ester suppresses proliferation and survival of TW2.6 human oral cancer cells via inhibition of Akt signaling. ,International Journal of Molecular Sciences ,14,5,pp8801-8817 (SCI)	汪宏達
2013	Chou HJ, Lai DM, Huang CW, McLennan IS, Wang H.-D., Wang PY. ,2013,BMP4 Is a Peripherally-Derived Factor for Motor Neurons and Attenuates Glutamate-Induced Excitotoxicity In Vitro.,PLOS ONE,8,3,ppe58441-	汪宏達
2013	Bruce KD, Hoxha S, Carvalho GB, Yamada R, Wang H.-D., Karayan P, He S, Brummel T, Kapahi P, Ja WW. ,2013, High carbohydrate-low protein consumption maximizes Drosophila lifespan. ,Experimental Gerontology ,10,48,pp1129-1135 (SCI)	汪宏達
2012	Kuo SY, Tu CH, Hsu YT, Wang HD, Wen RK, Lin CT, Wu CL, Huang YT, Huang GS, Lan TH, Fu TF. ,2012, A hormone receptor-based transactivator bridges different binary systems to precisely control spatial-temporal gene expression in Drosophila. ,PLoS One ,7,12,ppe50855.- (SCI)	汪宏達
2012	Huijie Liu, Xueren Wang, Horng-Dar Wang, JinJing Wu, Jing Ren, Lingfeng Meng, Qingfa Wu, Hansheng Dong, Jing Wu, Tzu-Yu Kao, Qian Ge, Zheng-xing Wu, Chiou-Hwa Yuh, Ge Shan. ,2012, Escherichia coli noncoding RNAs can affect gene expression and physiology of Caenorhabditis elegans. ,Nature Communications. ,3,pp1073- (SCI)	汪宏達
2012	Shih-Fen Chen, Ming-Lun Kang, Yi-Chun Chen, Hong-Wen Tang, Cheng-Wen Huang, Wan-Hua Li, Chun-Pu Lin, Chao-Yung Wang, Pei-Yu Wang, Guang-Chao Chen, and Horng-Dar Wang. ,2012, Autophagy-related Gene 7 Is Downstream of Heat Shock Protein 27 in the Regulation of Eye Morphology, Polyglutamine Toxicity, and Lifespan in Drosophila. ,Journal of Biomedical Science ,19,pp52- (SCI)	汪宏達
2012	Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA,... , Wang HD, et al. ,2012, Guidelines for the use and interpretation of assays for monitoring autophagy. ,Autophagy ,8,4,pp445-544 (SCI)	汪宏達
2012	Wang CT, Chen YC, Wang YY, Huang MH, Yen TL, Li H, Liang CJ, Sang TK, Ciou SC, Yuh CH, Wang CY, Brummel TJ, Wang, HD. ,2012, Reduced neuronal expression of ribose-5-phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in Drosophila. , Aging Cell* ,11,1,pp93-103 (SCI)	汪宏達
2012	Chao TC, Su WC, Huang JY, Chen YC, Jeng KS, Wang HD, Lai MM. ,2012, PSTPIP2, Proline-Serine-Threonine Phosphatase Interacting Protein 2, a Host Membrane-Deforming Protein, is critical for Membranous Web Formation in Hepatitis C Virus replication. ,Journal of Virology ,86,3,pp1739-1749 (SCI)	汪宏達
2012	Lu JW, Hsia Y, Yang WY, Lin YI, Li CC, Tsai TF, Chang KW, Shieh GS, Tsai SF, Wang, HD, Yuh CH. ,2012, Identification of the common regulators for hepatocellular carcinoma induced by hepatitis B virus X antigen in a mouse model. , Carcinogenesis ,33,1,pp209-219 (SCI)	汪宏達
2011	Lu JW, Hsia Y, Tu HC, Hsiao YC, Yang WY, Wang, H.-D., Yuh CH. ,2011, Liver development and cancer formation in zebrafish. ,Birth Defects Res C Embryo Today. ,93,2,pp157-172 (SCI)	汪宏達
2011	Chao CH, Tseng WF, Chan TM, Chen HL, Huang CB, Jang TH, Hsu HY, Wang HD, and Yuh, CH. ,2011, Mesendoderm gene regulatory networks in zebrafish. ,Global Journal of Biochemistry ,2,4,pp215-249 (Others)	汪宏達
2010	Chao CH, Wang HD, Yuh CH. ,2010, Complexity of Cis-regulatory Organization of Six3a during Forebrain and Eye Development in Zebrafish. , BMC Developmental Biology ,10,pp35- (SCI)	汪宏達
2010	Hsin IL, Sheu GT, Chen HH, Chiu LY, Wang HD, Chan HW, Hsu CP, Ko JL. ,2010, N-acetyl Cysteine Mitigates Curcumin-mediated Telomerase Inhibition through Rescuing of Sp1 Reduction in A549 cells. ,Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis. ,688,1-2,pp72-77 (SCI)	汪宏達
2009	T.-M. Chan, W. Longabaug, H. Bolouri, H.-L. Chen, W.-F. Tseng, C.-H. Chao, T.-H. Jang, Y.-I Lin, S.-C. Hung, H.-D. Wang, and C.-H. Yuh. ,2010,Developmental Gene Regulatory Networks in the Zebrafish Embryo. Biochim. Biophys., Acta-Gene Regul. Mech.,1789,pp279-298 (SCI)	汪宏達
2009	Chan TM, Chao CH, Wang HD, Yu YJ, Yuh CH. ,2009, Functional Analysis of the Evolutionarily Conserved Cis-Regulatory Elements on the Sox17 Gene in Zebrafish. ,Developmental Biology ,326,pp456-470 (SCI)	汪宏達
2009	Liu YL, Lu WC, Brummel TJ, Yuh CH, Lin PT, Kao TY, Li FY, Liao PC, Benzer S, Wang HD. ,2009, Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. ,Aging Cell* ,8,pp370-379 (SCI)	汪宏達
2008	Liao PC, Lin HY, Yuh CH, Yu LK, Wang HD. ,2008, The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration and apoptosis in Drosophila. , Biochemical and Biophysical Research Communications. ,376,pp637-641 (SCI)	汪宏達
2004	Horng-Dar Wang, P. Kazemi-Esfarjani, and S. Benzer. ,2004, Multiple-stress analysis for isolation of Drosophila longevity genes. , Proceedings of the National Academy of Science of the United States of America. ,101,pp12610-12615 (SCI)	汪宏達
2000	S.S. Johnson, N. Mandavia, H.-D. Wang, and D.L. Johnson,2000,Transcriptional Regulation of the TATA-Binding Protein by Ras Cellular Signaling., Mol. Cell. Biol.,20,pp5000-5009 (SCI)	汪宏達
1998	H.-D. Wang, A. Trivedi, and D.L. Johnson. ,1998,Regulation of RNA Polymerase I-Dependent Promoter by the Hepatitis B Virus X Protein via Activated Ras and TATA-binding Protein., Mol. Cell. Biol.,18,pp7086-7094 (SCI)	汪宏達
1995	H.-D. Wang, C.-H. Yuh, C.V. Dang, and D.L. Johnson.,1995,The Hepatitis B Virus X Protein Increases the Cellular Level of TATA-binding Protein which Mediates Transactivation of RNA Polymerase III Genes. ,Mol. Cell. Biol.,15,pp6720-6728 (SCI)	汪宏達
1994	H.-D. Wang, A. Trivedi, and D.L. Johnson.,1994,Hepatitis B Virus X Protein induces RNA Polymerase III-dependent Gene transcription and Increases Cellular TATA-Binding Protein by Activating the Ras Signaling Pathway., Mol. Cell. Biol. ,17,pp6838-6846 (SCI)	汪宏達

專書一覽
年度	專書類別	出版日期	專書名稱	著作人
2010		2010/09/00	丁信智，朱一民，江樵熹，汪宏達，高茂傑，張雍，陳永昌，曾繁根，焦傳金，黃郁棻，詹明修，劉英麟，蔡瑞瑩，鄭誠功，薛敬和，饒達仁 , 生命科學與工程, 藝軒出版社, 台灣台北, 978-957-41-7468-3（360）,2010/09	汪宏達

參與活動服務一覽
類別	活動名稱	主題	參與人
(研討會)	The 11th Annual Meeting on the Asia Pacific Society for Molecular Immunohistology （APSMI）	None. served as a poster reviewer.	汪宏達

專利一覽
年度	專利類別	專利名稱	西元年月	專利人
2013	其他	核酮糖五磷酸異構酶A促進癌細胞凋亡或抑制癌細胞轉移的方法	2013-11-00	汪宏達 / 汪宏達、喻秋華、邱士齊、邱于庭
2013	其他	早期階段檢測肝癌及預測肝癌轉移之方法	2013-09-00	汪宏達 / 汪宏達、喻秋華、蕭詠駿、邱于庭

校內榮譽一覽
得獎年度	獎項名稱	頒獎單位
2016	105年教師學術卓越獎勵	國立清華大學
2015	104年教師學術卓越獎勵	國立清華大學
2015	國立清華大學命科學院傑出教學獎	國立清華大學生命科學院
2015	國立清華大學教學優良教師教學獎勵	國立清華大學
2014	103年教師學術卓越獎勵	國立清華大學
2013	清大傑出學術研究出版獎勵	國立清華大學
2013	102年教師學術卓越獎勵	國立清華大學
2011	國立清華大學教學優良教師教學獎勵	國立清華大學
2010	Outstanding Thesis Award	College of Life Science, NTHU
2010	清大傑出學術研究出版獎勵	國立清華大學
2009	Outstanding Teaching Award	College of Life Science, NTHU
2008	國立清華大學生科院教師傑出論文獎	國立清華大學生命科學院

校外榮譽一覽
得獎年度	獎項名稱	頒獎單位
2016	榮台聯大合作研究優良壁報獎第一名 - 核糖5磷酸異構酶於大腸直腸癌之作用機轉研究	榮台聯大
2016	Editorial Board (2016~ present)	International Journal of Neurological Disorders & Interventions
2016	新竹縣政府醫事審議委員會委員(2016~2018)	新竹縣政府
2016	Editorial Board (2016 ~ present)	Journal of Pharmacovigilance and Pharmacotherapeuticsis
2016	Editorial Board (2016-present)	Madridge Journal of Neuroscience
2015	Editorial Board (2015-2018)	Reactive Oxygen Species
2014	Editorial Board	Science Postprint
2014	Editorial Board (2014-2016)	Adaptive Medicine
2014	Editorial Board	Journal of Biotechnology Science Research
2014	Editorial Board (2014-2016)	International Journal of Biological Sciences and Applications
2013	Editorial Board (2013-2015)	American Journal of Life Sciences
2013	中華民國優良廠商協會產學合作指導顧問暨評鑑委員會評鑑委員	中華民國優良廠商協會
2012	101年度肝病防治學術基金會研究獎助金	財團法人肝病防治學術基金會
2000	Postdoctoral Fellowship	John Douglas French Alzheimer’s Foundation.
2000	Postdoctoral Research Fellowship	National Institute of Aging, NIH.
1996	Charles & Charlotte Krown Fellowship	School of Pharmacy, USC.
1996	PhRMA Fellowship	Pharmaceutical Research and Manufactures of America Foundation.

學歷一覽
學校名稱	國別	系所	學位	起迄年月
加州理工學院	美國	生物系	博士後研究學者（with Dr. Seymour Benzer）	1999年01月 ~ 2004年06月
南加州大學	美國	分子藥學與毒物學系	博士後研究員（with Dr. Deborah L. Johnson）	1998年01月 ~ 1998年12月
南加州大學	美國	分子藥學與毒物學系	博士（Mentor: Dr. Deborah L. Johnson）	1992年09月 ~ 1997年12月

服務機關	職稱	部門/系所	起迄年月
國立清華大學	合聘教授	系統神經科學研究所	2015年08月 ~
國立清華大學	合聘副教授	系統神經科學研究所	2012年11月 ~ 2015年07月
國立清華大學	副教授	生物科技研究所 / 生命科學系	2009年08月 ~ 2015年07月
國立清華大學	助理教授	生物科技研究所 / 生命科學系	2004年08月 ~ 2009年07月
財團法人生物技術開發中心	研究助理	分生組	1989年06月 ~ 1991年06月

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清華大學生命科學院系統神經科學研究所