Yen-Chung ChangPersonal data of - Institute of Systems Neuroscience,NTHU

Faculty & Staff

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Name	Yen-Chung Chang
Personal website	http://life.nthu.edu.tw/~lscyc/

Category	Retired
Title	Professor
Administrative Affairs	Institute of Molecular Medicine / Institute of Systems Neuroscience / The Department of Life Sciences / Interdisciplinary Program of Life Science / Department of Medical Science
Discipline	Neurochemistry
Research expertise	Neurochemistry

Recent Publications
Year	Publication	Author
2011	Yen Yun-Hong, Chuang Chih-Fan, Chang Chia-Wei, and Chang Yen-Chung ,2011,A Study of the Spatial Protein Organization of the Postsynaptic Density Isolated from Porcine Cerebral Cortex and Cerebellum,Mol Cell Proteomics,M110,007138,pp1-20	Yen-Chung Chang
2011	Hsu, C.I., Hou, S.Y.T., Liou, Y.R. and Chang, Y.C.,2011,Morphological Changes and Synaptogenesis of Corticothalamic Neurons in the Somatosensory Cortex of Rat during Perinatal Development, Cerebral Cortex*,21,4,pp884-895 (SCI)	Yen-Chung Chang
2011	Chen, C.H., Chuang, S.C., Su, H.C., Hsu, W.L., Yew, T.R., Chang, Y.C., Yeh, S.R. and Yao, D.J.,2011,A three-dimensional flexible microprobe array for neural recording assembled through electrostatic actuation,Lab on a Chip,11,9,pp1647-1655 (SCI)	Yen-Chung Chang
2010	Wu, H.I., Cheng, G.H., Wong, Y.Y., Lin, C.M., Fang, W., Chow, W.Y. and Chang, Y.C.,2010,A lab-on-a-chip platform for studying the subcellular functional proteome of neuronal axons,Lab on a Chip*,10,5,pp647-653 (SCI)	Yen-Chung Chang
2010	Su, H.C., Lin, C.M., Yen, S.J., Chen, Y.C., Chen, C.H., Yeh, S.R., Fang, W., Chen, H., Yao, D.J., Chang, Y.C. and Yew, T.R. ,2010,A cone-shaped 3D carbon nanotube probe for neural recording.,Biosensors & Bioelectronics ,26,1,pp220-227 (SCI)	Yen-Chung Chang
2010	Su, H.C., Chen, C.H., Chen, Y.C., Yao, D.J., Chen, H., Chang, Y.C. and Yew, T.R. ,2010,Improving the adhesion of carbon nanotubes to a substrate using microwave treatment,Carbon,48,3,pp805-812 (SCI)	Yen-Chung Chang
2010	Lee, Y.T., Lin, C.W., Lin, C.M., Yeh, S.R., Chang, Y.C. and Fang, W,2010,A pseudo 3D glass microprobe array: glass microprobe with embedded silicon for alignment and electrical interconnection during assembly,Journal of Micromechanics and Microengineering ,20,2,pp025014- (SCI)	Yen-Chung Chang
2010	Hsu, C.I., Wang, T.C., Hou, S.Y.T., Chin, T.Y. and Chang, Y.C.* ,2010,Quantitative Study of the Developmental Changes in Calcium-Permeable AMPA Receptor-Expressing Neurons in the Rat Somatosensory Cortex,Journal of Comparative Neurology ,518,1,pp75-91 (SCI)	Yen-Chung Chang
2010	Chen, C.H., Su, H.C., Chuang, S.C., Yen, S.J., Chen, Y.C., Lee, Y.T., Chen, C., Yew, T.R., Chang, Y.C., Yeh, S.R. and Yao, D.J.,2010,Hydrophilic modification of neural microelectrode arrays based on multi-walled carbon nanotubes,Nanotechnology,21,48,pp485501- (SCI)	Yen-Chung Chang
2010	Chen, C.H., Chuang, S.C., Lee, Y.T., Chang, Y.C., Yeh, S.R. and Yao, D.J. ,2010,Three-dimensional flexible microprobe for recording the neural signal,Journal of Micro-Nanolithography Mems and Moems,9,3,pp031007- (SCI)	Yen-Chung Chang
2009	Chen, W.S., Chang, Y.C., Chen, Y.J., Chen, Y.J., Teng, C.Y., Wang, C.H. and Wu, T.Y. ,2010,Development of a prokaryotic-like polycistronic baculovirus expression vector by the linkage of two internal ribosome entry sites,Journal of Virological Methods,159,2,pp152-159 (SCI)	Yen-Chung Chang
2009	Yeh, S.R., Chen, Y.C., Su, H.C., Yew, T.R., Kao, H.H., Lee, Y.T., Liu, T.A., Chen, H., Chang, Y.C., Chang, P. and Chen, H,2009,Interfacing Neurons both Extracellularly and Intracellularly Using Carbon - Nanotube Probes with Long-Term Endurance, Langmuir,25,13,pp7718-7724 (SCI)	Yen-Chung Chang
2009	Lin, C.W., Lee, Y.T., Chang, C.W., Hsu, W.L., Chang, Y.C. and Fang, W.L. ,2009,Novel glass microprobe arrays for neural recording,Biosensors & Bioelectronics ,25,2,pp475-481 (SCI)	Yen-Chung Chang
2009	Cheng, W.Y., Hsu, W.L., Cheng, H.H., Huang, Z.H. and Chang, Y.C.,2009,An observation chamber for studying temperature-dependent and drug-induced events in live neurons using fluorescence microscopy,Analytical Biochemistry* ,386,1,pp105-112 (SCI)	Yen-Chung Chang
2009	Cheng, H.H., Huang, Z.H., Lin, W.H., Chow, W.Y. and Chang, Y.C.,2009,Cold-Induced Exodus of Postsynaptic Proteins From Dendritic Spines,Journal of Neuroscience Research* ,87,2,pp460-469 (SCI)	Yen-Chung Chang
2008	Horng W.C., Yen Y.H. and Chang, Y.C.* ,2008,A novel solid phase- and chemical crosslinking-based technology for determining protein localization in biological supramolecules, Proteomics,8,22,pp4642-4646 (SCI)	Yen-Chung Chang
2007	Huang, Z.H., Cheng, H.H., Wu, H.I, Tseng, S.H. and Chang, Y.C,2011,Studying the temperature-dependent events of live cells under confocal and epi-fluorescence microscopy using a solid-state heating/cooling system,Modern Research and Educational Topics in Microscopy,pp183-189	Yen-Chung Chang
2007	Lo, L.P., Liu, S.H. and Chang, Y.C.,2008,Assembling microtubules disintegrate the postsynaptic density in vitro,Cell Motility and the Cytoskeleton* ,64,1,pp6-18 (SCI)	Yen-Chung Chang
2007	Tzeng, D.W., Lin, M.H., Chen, B.Y., Chen, Y.C., Chang, Y.C. and Chow, W.Y. ,2007,Molecular and functional studies of tilapia (Oreochromis mossambicus) NMDA receptor NR1 subunits, Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology,146,3,pp402-411 (SCI)	Yen-Chung Chang
2007	Chang, C.W., Peng, S.C., Cheng, W.Y., Liu, S.H., Cheng, H.H., Huang, S.Y. and Chang, Y.C.* ,2007,Studying the protein-protein interactions in the postsynaptic density by means of immunoabsorption and chemical crosslinking,Proteomics,1,11,pp1499-1512 (SCI)	Yen-Chung Chang
2007	Zeng, H.C., Ho, Y.C., Chen, S.T., Wu, H.I., Tung, H.W., Fang, W.L. and Chang, Y.C.* ,2007,Studying the formation of large cell aggregates in patterned neuronal cultures,Journal of Neuroscience Methods ,165,1,pp72-82 (SCI)	Yen-Chung Chang
2006	Liu, S.H., Cheng, H.H., Huang, S.Y., Yiu, P.C. and Chang, Y.C.,2006,Studying the protein organization of the postsynaptic density by a novel solid phase- and chemical cross-linking-based technology,Molecular & Cellular Proteomics* ,5,6,pp1019-1032 (SCI)	Yen-Chung Chang
2006	Huang, Z.H., Wu, H.J., Yeh, C.C., Chou, Y.C. and Chang, Y.C.,2006,Dendritic spines of developing rat cortical neurons in culture,Chinese Journal of Physiology* ,49,1,pp39-45 (SCI)	Yen-Chung Chang
2006	Cheng, H.H., Liu, S.H., Lee, F.C., Lin, Y.S., Huang, Z.H., Hsu, C.I., Chen, Y.C. and Chang, Y.C.,2006,Heavy chain of cytoplasmic dynein is a major component of the postsynaptic density fraction,Journal of Neuroscience Research*,84,2,pp244-254 (SCI)	Yen-Chung Chang
2002	2002,Lin, Y.-C., Huang, Z.-H., Jan, I.S., Yeh, C.-C., Wu, H.-J., Chou, Y.C. and Chang, Y.-C. (2002) Development of excitatory synapses in cultured neurons dissociated from the cortices of rat embryos and rat pups at birth. J. Neurosci. Res. 67, 484-493. ,	Yen-Chung Chang
2002	2002,Jan, H.-H., Chen, I.-T., Tsai, Y.-Y. and Chang, Y.-C. (2002) Structural roles of the zinc ions bound to the postsynaptic density. J. Neurochem. 83, 525-534. ,	Yen-Chung Chang
2002	2002,Srisalam, S., Wang, H.-M., Kumar, T.K.S., Rajalingam, D., Sivaraja, V., Sheu, H.-S., Chang, Y.-C. and Yu, C. (2002) Amyloid-like fibril formation in an all b-barrel protein involves the formation of partially structured intermediate(s). J. Biol. Chem. 277, 19027-19036.(SCI) ,	Yen-Chung Chang
2000	2000,Hon, Y.S., Chang, Y.-C. and Chu, K.P. (2000) Synthesis of 3-substituted –L-glutamic acid analogues for neuroexcitatory activity studies. J. Chinese Chem. Soc. 47, 91-102. ,	Yen-Chung Chang
2000	2000,Sui, C.-W., Chow, W.-Y. and Chang, Y.-C. (2000) Effects of disulfide bonds formed during isolation process on the structure of the postsynaptic density. Brain Res. 873, 268-273. ,	Yen-Chung Chang
1999	1999, Lai, S.-L., Chiang, S.-F., Chen, I.-T., Chow, W.-Y. and Chang, Y.-C. (1999) Inter-protein disulfide bonds formed during isolation process tighten the structure of the postsynaptic density. J. Neurochem.73, 2130-2138. ,	Yen-Chung Chang
1998	1998, Lai, S.-L., Ling, S.-C., Kuo, L.-H., Shu, Y.-C., Chow, W.-Y. and Chang, Y.-C. (1998) Characterization of granular particles isolated from postsynaptic densities. J. Neurochem. 71, 1694-1701. ,	Yen-Chung Chang
1998	1998,Chang, S.-M., Wu, Y.-M., Chang, Y.-C., Hsu, Y.-C., Hsu, H.Y., Chen, C.-C. and Chow, W.-Y. (1998) Molecular and electrophysiological characterization of fGluR3, an ionotropic glutamate receptor subunit of a teleost fish. Mol. Brain Res. 57, 211-220. ,	Yen-Chung Chang
1997	1997,Tyan, S.-H., Sue, T.-Y., Hon, Y.-S., Gean, P.-W. and Chang, Y.-C. (1997) A novel NMDA receptor antagonist protects against N-methyl-D-aspartate- and glutamate-induced neurotoxicity in the goldfish retina. Eur. J. Pharmacol. 321, 171-179. ,	Yen-Chung Chang
1996	1996,Tyan, S.-H., Chang, S.-M., Gean, P.-W., Hon, Y.-S. and Chang, Y.-C. (1996) 4(R)- and 4(S)- (5-phenylpentyl)-glutamic acids attenuate excitatory postsynaptic potential on hippocampus without inhibiting postsynaptic NMDA and AMPA receptors. Chinese J. Physiol. 39, 131-137. ,	Yen-Chung Chang
1996	1996,Chang, Y.-C., Wu, T.-Y., Li, B.-F., Gao, L.-H., Liu, C.-Y. and Wu, C.-L. (1996) Purification and biochemical characterization of AMPA/kainate-sensitive L-glutamate receptors of porcine brain. Biochem. J. 319, 49-57. ,	Yen-Chung Chang
1996	1996,Wu, T.-Y., Liu, C.-Y. and Chang, Y.-C. (1996) A study of the oligomeric state of AMPA-preferring glutamate receptors in the synaptic junctions of porcine brain. Biochem. J. 319, 331-339. ,	Yen-Chung Chang
1994	1994,Wu, T.-Y. and Chang, Y.-C. (1994) Hydrodynamic and pharmacological characterization of putative AMPA/kainate-sensitive L-glutamate receptors solubilized from porcine brain. Biochem. J. 300, 365-371. ,	Yen-Chung Chang
1993	1993,Chang, Y.-C., Hon, Y.-S., Chow, W.-Y., Lin, T.-A., Jan, P.-Y. and Wang, C.-M. (1993) Study of stereoselectivity of L-glutamate receptors by synthetic 4(R)-and 4(S)-substituted L-glutamate analogues. Brain Res. 604, 86-89. ,	Yen-Chung Chang
1993	1993,Chang, Y.-C., Chiu, S.-J. and Kao, K.-P. (1993) Beta-N-methylamino-L-alanine induces behavioral changes and a decrease of glutamate receptors. Chinese J. Physiol. 36, 79-84. ,	Yen-Chung Chang
1992	1992,Tong, C.-K., Pang, M.-P. and Chang, Y.-C. (1992) Characterization of L-glutamate and kainate binding sites of the brain of a freshwater fish Telapilia monsanbica. Neuroscience 49, 237-246. ,	Yen-Chung Chang
1992	1992,Chang, Y.-C. (1992) Efficient precipitation and accurate quantitation of detergent-solubilized membrane proteins. Anal. Biochem. 205, 22-26. ,	Yen-Chung Chang
1991	1991,Hon, Y.-S., Chang, Y.-C. and Gong, M.-L. (1991) The studies of a-alkylation of N-tert-BOC-5(S)-tert-butyldimethylxymethyl-2-pyrrolidinones. Bull. Inst. Chem. Academia Sinica. 38, 23031. ,	Yen-Chung Chang
1991	1991,Chang, Y.-C., Lin, I.-H., Lee, Y.-H. and Leng, C.-H. (1991) Solubilization, characterization and partial purification of AMPA, quisqualate, kainate-sensitive L-[3H]glutamate binding sites from porcine brain synaptic junctions. J. Neurochem. 57, 1921-1926. ,	Yen-Chung Chang
1990	1990,Hon, Y.-S., Chang, Y.-C. and Gong, M.-L. (1990) Efficient enantioselective syntheses of (4R)-substituted (2S)-glutamic acids. Heterocycles 31, 191-196. ,	Yen-Chung Chang
1990	1990,Chang, Y.-C., Hon, Y.-S. and Chow, W.-Y. (1990) Solubilization and characterization of glutamate binding sites from porcine brain. Neurochem. Int. 16, 173-185. ,	Yen-Chung Chang
1988	1988,Chang, Y.-C. and Gottlieb, D.I. (1988) Characterization of the protein purified with monoclonal antibodies to glutamic acid decarboxylase. J. Neurosci. 8, 2123-2130. ,	Yen-Chung Chang
1987	1987,Chang, Y.-C., Soman, G. and Graves, D.J. (1987) Identification of an enzymatic activity that hydrolyzes protein bound ADP-ribose in skeletal muscle. Biochem. Biophys. Res. Comm. 139, 932-939. ,	Yen-Chung Chang
1987	1987,Chang, Y.-C., Scott R.D. and Graves, D.J. (1987) Function of pyridoxal-5‘-phosphate in glycogen phosphorylase: A model study using 6-fluoro-5’-deoxypyridoxal and 5‘-deoxypyridoxal reconstituted enzyme. Biochemistry 26, 360-367. ,	Yen-Chung Chang
1986	1986,Chang, Y.-C., Scott, R.D. and Graves, D.J. (1986) Function of pyridoxal-5‘-phosphate in glycogen phosphorylase: F-19 NMR and kinetic studies of phosphorylase reconstituted with 6-fluoropyridoxal and 6-fluoropyridoxal phosphate. Biochemistry 25, 1932-1939. ,	Yen-Chung Chang
1986	1986,Gottlieb, D.I., Chang, Y.-C. and Schwob, J. (1986) Monoclonal antibodies of glutamic acid decarboxylase. Proc, Natl. Acad. Sci. USA 83, 8808-8812. ,	Yen-Chung Chang
1985	1985,Arus, C., Chang, Y.-C. and Barany, M. (1985) N-acetylaspartate as an intrinsic thermometer for H-1 NMR of sliced brain. J. Magn.Reson. 63, 376-379. ,	Yen-Chung Chang
1985	1985,Barany, M., Chang, Y-C., Arus, C., Rustan, T. and Frey. W.H. (1985) Increased glycerol-3-phosphocholine in postmortem Alzheimer‘s brain. Lacet I, 517. ,	Yen-Chung Chang
1985	1985,Barany, M., Chang, Y.-C. and Arus, C. (1985) Effects of halothane on the natural abundance C-13 NMR spectra of excised rat brain. Biochemistry 24, 7911-7917. ,	Yen-Chung Chang
1985	1985,Barany, M., Arus, C. and Chang, Y.-C. (1985) Natural abundance C-13 NMR of brain. Magn. Reson. Med. 2, 289-295. ,	Yen-Chung Chang
1985	1985,Arus, C., Chang, Y.-C. and Barany, M. (1985) The separation of phosphocreatine from creatine and pH determination in frog muscle by natural abundance C-13 NMR. Biochem. Biophys. Acta. 844, 91-93. ,	Yen-Chung Chang
1985	1985,Chang, Y.-C., Arus, C. and Barany, M. (1985) Characterization of the broad resonance in P-31 NMR spectra of excised rat brain. Physiol. Chem. Phys. Med. NMR 17, 143-154. ,	Yen-Chung Chang
1985	1985,Scott, R.D., Chang, Y.-C., Graves, D.J. and Metzler, D.E. (1985) Studies of 6-fluoropyridoxal and 6-fluoropyridoxamine 5‘-phosphate in cytosolic aspartate aminotransferase. Biochemistry 24, 7668-7681. ,	Yen-Chung Chang
1985	1985,Chang, Y.-C. and Graves, D.J. (1985) Use of 6-fluoroderivatives of pyridoxal phosphate in the study of coenzyme function in glycogen phosphorylase. J. Biol. Chem. 260, 2709-2714. ,	Yen-Chung Chang
1983	1983,Soman, G., Chang, Y.-C. and Graves, D.J. (1983) Effects of oxyanions of early transition metals on rabbit skeletal muscle phosphorylase. Biochemistry 22, 4993-4998. ,	Yen-Chung Chang
1983	1983,Chang, Y,-C., McCalmont, T. and Graves, D.J. (1983) Functions of 5‘-phosphate group of pyridoxal 5’-phosphate in phosphorylase: A study using pyridoxal reconstituted enzyme as a model system. Biochemistry 22, 4987-4993. ,	Yen-Chung Chang
1983	1983,Graves, D.J., Soman, G., Hurst, M. and Chang, Y.-C. (1983) Involvement of guanidinogroup in anion-binding sites and in enzyme-catalyzed covalent modification reactions, Current Topics in Cellular Regulation 24, 181-190. ,	Yen-Chung Chang
1983	1983,Scott, R.D., Chang, Y-C., Graves, D.J. and Metzler, D.E. (1983) NMR study of 5-fluoro-pyridoxal phosphate-containing cytosolic aspartate aminotransferase, in “Chemical and biochemical aspects of vitamin B6 catalysis”, vol. 2, R.Alan ed., Liss Inc., New York,pp.249-257. ,	Yen-Chung Chang
1981	1981,Chen, H.-H., Hsu, C.-H., Chang, Y.-C. and Wei, H.-H. (1981) Mossbauer spectroscopic studies of trifluorostannate (ll) in frozen aqueous solutions. Radiochem. Radioanal. Letters 59, 167-171. ,	Yen-Chung Chang
1981	1981,Chen, H.-H., Hsu, C.-H., Chang, Y.-C. and Wei, H.-H. (1981) Mossbauer spectroscopic studies of trifluorostannate (ll) in frozen aqueous solutions. Radiochem. Radioanal. Letters 59, 167-171. ,	Yen-Chung Chang

Institute of Systems Neuroscience,NTHU

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